Bronchial reactivity in infants in acute respiratory failure with viral bronchiolitis
- 1 January 1989
- journal article
- research article
- Published by Wiley in Pediatric Pulmonology
- Vol. 6 (4), 253-259
- https://doi.org/10.1002/ppul.1950060408
Abstract
Airway reactivity and the effects of bronchodilators in infants are controversial. We studied the response to bronchodilator treatment in 14 mechanically ventilated infants (mean age, 2.74 months; range, 0.6–5.9) in respiratory failure caused by respiratory syncytial virus (RSV)-associated bronchiolitis. Sixteen infants without lung disease, undergoing elective surgery, provided normal values. Maximum expiratory deflation flow-volume (DFV) curves were produced by manual inflation of the lungs with an anesthesia bag to a predetermined static airway pressure followed by rapid deflation with a negative airway pressure before and after administration of bronchodilator. At baseline, the bronchiolitis group had a forced vital capacity (FVC) of 34.5 ± 3.6 ml/kg compared with 41.8 ± 1.5 ml/kg in the normal group; maximum expiratory flow rate at 25% of FVC (MEF25) was 10.2 ± 2.0 ml/kg/s compared with 27.3 ± 2.0 ml/kg/s in the normal group. The clinical and radiologic impression was severe lower airway obstruction and air trapping. After administration of bronchodilator, FVC did not increase significantly, but MEF25isov increased by over 30% in 13 of 14 infants. Mean MEF25increased by 148 ± 43.2% to 21.7 ± 3.9 ml/kg/s (P< 0.01). These findings indicate that during the acute phase of severe RSV-positive bronchiolitis most infants have airway reactivity that responds positively to bronchodilator treatment.Keywords
This publication has 20 references indexed in Scilit:
- Normal pulmonary function measurements and airway reactivity in childhood after mild bronchiolitisThe Journal of Pediatrics, 1985
- Bronchodilator response during acute viral bronchiolitis in infancyPediatric Pulmonology, 1985
- Ineffectiveness of ipratropium bromide in acute bronchiolitis.Archives of Disease in Childhood, 1983
- Nebulised therapy in acute severe bronchiolitis in infancy.Archives of Disease in Childhood, 1983
- Increased incidence of bronchial reactivity in children with a history of bronchiolitisThe Journal of Pediatrics, 1981
- Alpha and beta adrenergic stimulants in bronchiolitis and wheezy bronchitis in children under 18 months of age.Archives of Disease in Childhood, 1978
- At what age do bronchodilator drugs work?Archives of Disease in Childhood, 1978
- Effect of bronchodilators on respiratory resistance in infants and young children with bronchiolitis and wheezy bronchitis.Archives of Disease in Childhood, 1975
- Acute Respiratory Failure in Infants with BronchiolitisAnesthesiology, 1968
- The effect of breathing 40 per cent oxygen on the arterial blood gas tensions of babies with bronchiolitisThe Journal of Pediatrics, 1963