Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation
- 14 December 2009
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 425 (1), 53-54
- https://doi.org/10.1042/bj20091428
Abstract
Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.Keywords
This publication has 6 references indexed in Scilit:
- Discovery and Exploitation of Inhibitor-resistant Aurora and Polo Kinase Mutants for the Analysis of Mitotic NetworksPublished by Elsevier BV ,2009
- The selectivity of protein kinase inhibitors: a further updateBiochemical Journal, 2007
- The specificities of protein kinase inhibitors: an updateBiochemical Journal, 2003
- Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochemical Journal, 2000
- Use of a drug‐resistant mutant of stress‐activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580FEBS Letters, 1999
- Control of p70 S6 kinase by kinase activity of FRAP in vivoNature, 1995