Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome
- 1 July 2013
- journal article
- research article
- Published by Elsevier BV in Cancer Cell
- Vol. 24 (1), 90-104
- https://doi.org/10.1016/j.ccr.2013.05.006
Abstract
• IRAK1 is overexpressed and activated in ∼25% of MDSs • Genetic and pharmacological inhibition of IRAK1 is effective against human MDSs • IRAK1 is necessary for survival, proliferation, and NF-κB activation in MDS clones • Coinhibition of IRAK1 and BCL2 collaboratively and selectively targets MDS clonesKeywords
This publication has 44 references indexed in Scilit:
- NF-κB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignanciesProceedings of the National Academy of Sciences of the United States of America, 2011
- miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in miceThe Journal of Experimental Medicine, 2011
- Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout miceLeukemia, 2010
- Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cellsLeukemia, 2010
- Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotypeNature Medicine, 2009
- ToppGene Suite for gene list enrichment analysis and candidate gene prioritizationNucleic Acids Research, 2009
- Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB ActivationMolecular and Cellular Biology, 2008
- Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AMLBlood, 2008
- NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesProceedings of the National Academy of Sciences, 2006
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences of the United States of America, 2005