Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children
- 1 May 2018
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pediatric Critical Care Medicine
- Vol. 19 (5), e235-e241
- https://doi.org/10.1097/pcc.0000000000001468
Abstract
Objectives: To describe the need for transfusion and short- and long-term evolutions of pediatric sickle cell disease patients with acute chest syndrome for whom early continuous noninvasive ventilation represented first-line treatment. Design: Single-center retrospective chart study in PICU. Setting: A tertiary and quaternary referral PICU. Patients: All sickle cell disease patients 5–20 years old admitted with confirmed acute chest syndrome and not transfused in the previous month were included. Interventions: None. Measurements and Main Results: Demographic data, laboratory and radiologic findings, transfusions, invasive ventilation, oxygen and noninvasive ventilation settings, duration of opioid treatment, length of hospital stay, and severe sickle cell disease complications in the ensuing 2 years were extracted from medical charts. Sixty-six acute chest syndrome in 48 patients were included. Continuous early noninvasive ventilation was well tolerated in 65 episodes, with positive expiratory pressure 4 cm H2O and pressure support 10 cm H2O (median) administered continuously, then discontinued during 7 days (median). No patient necessitated invasive ventilation or died. Twenty-three acute chest syndrome (35%) received transfusions; none received blood exchange. Transfused patients had more frequent upper lobe radiologic involvement, more severe anemia, higher reticulocyte counts, and higher C-reactive protein than nontransfused patients. Their evolution was more severe in terms of length of opioid requirement, length of noninvasive ventilation treatment, overall time on noninvasive ventilation, and length of stay. At 2-year follow-up after the acute chest syndrome episode, no difference was observed between the two groups. Conclusions: Early noninvasive ventilation combined with nonroutine transfusion is well tolerated in acute chest syndrome in children and may spare transfusion in some patients. Early recognition of patients still requiring transfusion is essential and warrants further studies.Keywords
This publication has 30 references indexed in Scilit:
- Acute chest syndrome: sickle cell diseaseEuropean Journal of Haematology, 2011
- Non‐invasive ventilation on a pediatric intensive care unit: Feasibility, efficacy, and predictors of successPediatric Pulmonology, 2011
- Delayed hemolytic transfusion reaction in children with sickle cell diseaseHaematologica, 2011
- Predictive factors for the outcome of noninvasive ventilation in pediatric acute respiratory failure*Pediatric Critical Care Medicine, 2010
- Outcome of children with sickle cell disease admitted to intensive care - a single institution experienceBritish Journal of Haematology, 2010
- Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adultsTransfusion, 2009
- Impact of acute chest syndrome on lung function of children with sickle cell diseaseThe Journal of Pediatrics, 2006
- Noninvasive positive pressure ventilation: Five years of experience in a pediatric intensive care unit*Pediatric Critical Care Medicine, 2006
- Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell DiseaseThe New England Journal of Medicine, 2000
- Effect of transfusion in acute chest syndrome of sickle cell diseaseThe Journal of Pediatrics, 1995