A Reactive Oxygen Species (ROS)‐Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells
- 28 May 2013
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 52 (27), 6926-6929
- https://doi.org/10.1002/anie.201209633
Abstract
Stimuli‐responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer‐targeted gene delivery. A ROS‐responsive thioketal‐based cationic polymer was synthesized and functionalization with a cancer‐targeting peptide led to selective and enhanced gene transfection in prostate cancer cells (see scheme).Keywords
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