Intake of 1-Deoxynojirimycin Suppresses Lipid Accumulation through Activation of the β-Oxidation System in Rat Liver
- 28 October 2009
- journal article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 57 (22), 11024-11029
- https://doi.org/10.1021/jf903132r
Abstract
It was recently shown that administration of 1-deoxynojirimycin (DNJ) extracted from mulberry suppresses an increase in postprandial blood glucose in humans. These findings are of interest, but other physiological functions of DNJ are unknown. This study examined the effects of oral administration of DNJ (1 mg/kg of body weight/day) or mulberry extracts enriched in DNJ (meDNJ; 100 or 200 mg of extract/kg of body weight/day, equivalent to 0.53 or 1.06 mg of DNJ/kg of body weight/day) in male Sprague−Dawley rats for 4 weeks. DNJ and meDNJ enhanced expression of adiponectin mRNA in white adipose tissue; increased plasma adiponectin levels, enhanced expression of AMPK mRNA, activated the β-oxidation system, and suppressed lipid accumulation in the liver. Intake of DNJ and meDNJ did not cause hepatic dysfunction and led to a reduction of oxidative stress. These results indicate the efficacy and safety of DNJ and meDNJ.This publication has 26 references indexed in Scilit:
- Occurrence of Orally Administered Mulberry 1-Deoxynojirimycin in Rat PlasmaJournal of Agricultural and Food Chemistry, 2007
- Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acidin Vitroandin VivoBioscience, Biotechnology, and Biochemistry, 2007
- Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in HumansJournal of Agricultural and Food Chemistry, 2007
- Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cellsBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
- Conjugated docosahexaenoic acid inhibits lipid accumulation in ratsThe Journal of Nutritional Biochemistry, 2006
- Tumor growth suppression by -eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidationCarcinogenesis: Integrative Cancer Research, 2004
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Polyhydroxylated Alkaloids Isolated from Mulberry Trees (Morus alba L.) and Silkworms (Bombyx mori L.)Journal of Agricultural and Food Chemistry, 2001
- Polyhydroxylated alkaloids — natural occurrence and therapeutic applicationsPhytochemistry, 2001
- Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese menAtherosclerosis, 1994