Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients
- 9 May 2009
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 36 (9), 1377-1382
- https://doi.org/10.1007/s00259-009-1157-2
Abstract
Sentinel lymph node dissection (SLND) has replaced extended lymphadenectomy for nodal staging in several solid tumours. We present our results of SLND in prostate cancer in regard to detection and false-negative rate. In a 2-day protocol about 300 MBq 99mTc-nanocolloid are injected into the prostate. Two hours later static scans of the pelvis are performed to get information about the number and location of radioactive lymph nodes. During surgery the radioactive nodes are excised with the help of a gamma probe and sent separately to the pathologist. The histological procedure includes haematoxylin and eosin staining, serial sections and immunohistochemistry. Since 1999, a total of 2,020 men underwent SLND alone or in combination with either standard or extended lymphadenectomy after radical retropubic prostatectomy. Lymph nodes positive for metastases were found in 16.7% of patients. The scintigraphic detection rate was 97.6% and the intraoperative detection rate 98%. For 187 lymph node-positive men who had either standard or extended lymphadenectomy in addition to SLND the false-negative rate could be calculated, resulting in false-negative findings in 11 of 187 patients (6%). Our results demonstrate that SLND in prostate cancer is a reliable procedure for nodal staging.Keywords
This publication has 21 references indexed in Scilit:
- Lymphadenectomy in Prostate CancerFrontiers of radiation therapy and oncology, 2008
- Is Pelvic Lymph Node Dissection Necessary in Patients with a Serum PSA<10ng/ml Undergoing Radical Prostatectomy for Prostate Cancer?European Urology, 2006
- American Society of Clinical Oncology Guideline Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast CancerJournal of Clinical Oncology, 2005
- DETECTION OF EARLY LYMPH NODE METASTASES IN PROSTATE CANCER BY LAPAROSCOPIC RADIOISOTOPE GUIDED SENTINEL LYMPH NODE DISSECTIONJournal of Urology, 2005
- A concept for the clinical implementation of sentinel lymph node biopsy in patients with breast carcinoma with special regard to quality assuranceCancer, 2005
- EAU Guidelines on Penile CancerEuropean Urology, 2004
- Prostate Lymphoscintigraphy and Radio-Guided Surgery for Sentinel Lymph Node Identification in Prostate CancerUrologia Internationalis, 2003
- Disease Progression and Survival of Patients With Positive Lymph Nodes After Radical Prostatectomy. Is there a Chance of Cure?Journal of Urology, 2003
- The Sentinel Node in Breast Cancer — A Multicenter Validation StudyThe New England Journal of Medicine, 1998
- Technical Details of Intraoperative Lymphatic Mapping for Early Stage MelanomaArchives of Surgery, 1992