A Comprehensive Development Strategy in Buccal Drug Delivery
- 30 November 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in AAPS PharmSciTech
- Vol. 11 (4), 1703-1712
- https://doi.org/10.1208/s12249-010-9546-1
Abstract
This work combines several methods in an integrated strategy to develop a matrix for buccal administration. For this purpose, tablets containing selected mucoadhesive polymers loaded with a model drug (omeprazole), free or in a complexed form with cyclodextrins, and in the absence and presence of alkali agents were subjected to a battery of tests. Mucoadhesion studies, including simple factorial analysis, in vitro release studies with both model-dependent and model-independent analysis, and permeation studies were performed. Mucoadhesive profiles indicated that the presence of the drug decreases the mucoadhesion profile, probably due its hydrophobic character. In tablets loaded with the drug complexed with β-cyclodextrin or methyl-β-cyclodextrin, better results were obtained with the methylated derivative. This effect was attributed to the fact that in the case of β-cyclodextrin, more hydroxyl groups are available to interact with the mucoadhesive polymers, thus decreasing the mucoadhesion performance. The same result was observed in presence of the alkali agent (l-arginine), in this case due to the excessive hydrophilic character of l-arginine. Drug release from tablets was also evaluated, and results suggested that the dissolution profile with best characteristics was observed in the matrix loaded with omeprazole complexed with methyl-β-cyclodextrin in the presence of l-arginine. Several mathematical models were applied to the dissolution curves, indicating that the release of the drug, in free or in complexed state, from the mucoadhesive matrices followed a super case II transport, as established on the basis of the Korsmeyer–Peppas function. The feasibility of drug buccal administration was assessed by permeation experiments on porcine buccal mucosa. The amount of drug permeated from mucoadhesive tablets presented a maximum value for the system containing drug complexed with the methylated cyclodextrin derivative in presence of l-arginine. According to these results, the system containing the selected polymer mixture and the drug complexed with methyl-β-cyclodextrin in presence of l-arginine showed a great potential as a buccal drug delivery formulation, in which a good compromise among mucoadhesion, dissolution, and permeation properties was achieved.Keywords
This publication has 51 references indexed in Scilit:
- The Role of l-arginine in Inclusion Complexes of Omeprazole with CyclodextrinsAAPS PharmSciTech, 2010
- Effect of Drug Solubility on Polymer Hydration and Drug Dissolution from Polyethylene Oxide (PEO) Matrix TabletsAAPS PharmSciTech, 2008
- In vitro toxicity and permeation of cyclodextrins in Calu-3 cellsJournal of Controlled Release, 2008
- Physical and thermal characterisation of chiral omeprazole sodium saltsJournal of Pharmaceutical and Biomedical Analysis, 2006
- Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatographyJournal of Pharmaceutical and Biomedical Analysis, 2006
- Solid state interactions between the proton pump inhibitor omeprazole and various enteric coating polymersJournal of Pharmaceutical Sciences, 2006
- The basics and underlying mechanisms of mucoadhesionAdvanced Drug Delivery Reviews, 2005
- In vitro controlled release of vinpocetine–cyclodextrin–tartaric acid multicomponent complexes from HPMC swellable tabletsJournal of Controlled Release, 2005
- Validation of the spectrophotometric determination of omeprazole and pantoprazole sodium via their metal chelatesJournal of Pharmaceutical and Biomedical Analysis, 2003
- The effect of a changing diffusion coefficient in super-Case II polymer-penetrant systemsIMA Journal of Applied Mathematics, 1995