Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice
Open Access
- 1 February 2002
- journal article
- Published by FapUNIFESP (SciELO) in Brazilian Journal of Medical and Biological Research
- Vol. 35 (2), 237-242
- https://doi.org/10.1590/s0100-879x2002000200013
Abstract
Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FarmacologiaUNIFESP, EPM, Depto. de FarmacologiaSciELKeywords
This publication has 18 references indexed in Scilit:
- Effects of buspirone on an animal model of tardive DyskinesiaProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1999
- Effects of continuous exposure to light on behavioral dopaminergic supersensitivityBiological Psychiatry, 1999
- Effects of haloperidol and GM1 ganglioside treatment on striatal D2 receptor binding and dopamine turnoverLife Sciences, 1998
- Effects of buspirone on dopaminergic supersensitivityLife Sciences, 1997
- Effects of monosialoganglioside on dopaminergic supersensitivityLife Sciences, 1995
- Effects of single and long-term metoclopramide administration on open field and stereotyped behavior of ratsEuropean Journal of Pharmacology, 1988
- Dopaminergic supersensitivity after long-term bromopride treatmentPhysiology & Behavior, 1987
- Dopaminergic effects of buspirone, a novel anxiolytic agentBiochemical Pharmacology, 1983
- Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of ratsPsychopharmacology, 1979
- Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in BrainScience, 1977