Crystal structure of cyclin-dependent kinase 2
- 17 June 1993
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 363 (6430), 595-602
- https://doi.org/10.1038/363595a0
Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4Å resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix—loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.Keywords
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