Topical ciclosporin in the treatment of ocular surface disorders
Open Access
- 1 October 2005
- journal article
- review article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 89 (10), 1363-1367
- https://doi.org/10.1136/bjo.2005.070888
Abstract
Mounting evidence suggests that inflammation is the key factor in the pathogenesis of various ocular surface diseases, with a complex interplay of genetic, environmental, and psychosocial factors. Management of these conditions is often challenging. Topical corticosteroids, with their associated side effects, are the mainstay of current treatments for patients with vision threatening disease. Ciclosporin A is an immunomodulator that specifically inhibits T lymphocyte proliferation. Recently, a topical ciclosporin preparation was approved by the US Food and Drug Administration and became available for use in ophthalmology. Given the increasing use of ciclosporin eye drops, the goal of this article is to provide the reader with an overview of the well established uses of ciclosporin and to help refine the questions that should be addressed by future investigations.Keywords
This publication has 99 references indexed in Scilit:
- Changes in the tear film and ocular surface from dry eye syndromeProgress in Retinal and Eye Research, 2004
- PCR for varicella zoster virus genome negative in corneal epithelial cells of patients with Thygeson's superficial punctate keratitisEye, 2004
- A randomized trial of topical cyclosporin 0.05% in topical steroid–resistant atopic keratoconjunctivitisOphthalmology, 2004
- Topical Cyclosporine in the Management of Shield UlcersCornea, 2004
- Thygeson's superficial punctate keratitis: Ten years' experienceOphthalmology, 2004
- Bilateral Keratoconjunctivitis Associated with Lichen PlanusCornea, 2004
- The role of the lacrimal functional unit in the pathophysiology of dry eyeExperimental Eye Research, 2003
- Vernal Keratoconjunctivitis in Nigerians: 109 Consecutive CasesTropical Doctor, 2003
- Immuno-suppressive drug treatment of keratitis sicca, including an example of lichen planus of the conjunctiva.1968
- Further observations on superior limbic keratoconjunctivitis.1967