ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia: a retrospective study
- 22 October 2013
- journal article
- Published by Taylor & Francis Ltd in Gynecological Endocrinology
- Vol. 30 (1), 48-52
- https://doi.org/10.3109/09513590.2013.848427
Abstract
To determine whether intracytoplasmic sperm injection (ICSI) outcome with testicular sperm is superior to that of ejaculated sperm in men with incomplete necrozoospermia, defined as sperm viability ≥5 to ≤45%. Retrospective study at a Reproductive Medicine Center of a tertiary referral hospital. A total of 231 couples with male infertility due to incomplete necrozoospermia underwent 342 ICSI cycles with freshly ejaculated sperm (ICSI-ejaculated) and 182 cycles with testicular sperm (ICSI-TESE). Overall 1624 MII oocytes were injected in the ICSI-ejaculated group with a fertilisation rate of 60.8%, while in ICSI- TESE cycles the fertilisation rate was 59.6% in 874 MII oocytes. The cleavage rate was higher in ICSI-ejaculated cycles than in ICSI-TESE cycles (96.3% versus 92.9%; p = 0.004). However, the pregnancy and implantation rates per cycle were significantly higher in the ICSI-TESE group (67/182, 36.8% versus 68/342, 19.9% (p = 0.0001); and 23.7% versus 12.7% (p = 0.0001), respectively). The miscarriage rate was similar (ICSI-ejaculated 26.5% versus ICSI-TESE 17.9%, p = 0.301). Live birth rate per cycle in the ICSI-ejaculated group was significantly lower than in the ICSI-TESE (13.7% versus 28.6%, p = 0.0001). In cases of persistent necrozoospermia, testicular sperm should be favoured over ejaculated sperm. These data call for more research to understand the pathophysiology of refractory necrozoospermia.Keywords
This publication has 34 references indexed in Scilit:
- Absolute asthenozoospermia and ICSI: what are the options?Human Reproduction Update, 2011
- Analysis of the outcome of intracytoplasmic sperm injection using fresh or frozen spermBJU International, 2010
- Testicular spermatozoa have statistically significantly lower DNA damage compared with ejaculated spermatozoa in patients with unsuccessful oral antioxidant treatmentFertility and Sterility, 2010
- Semen anomalies due to voiding defects of the ampullo-vesicular tract Infertility due to ampullo-vesicular voiding defects: Samenveränderungen nach Entleerungsstörungen von Bläschendrüsen und Ampullen Infertilität durch Entleerungsstörungen von BläschendrAndrologia, 2009
- Value of Serum Antisperm Antibodies in Diagnosing Obstructive AzoospermiaJournal of Urology, 2009
- Results of in vitro fertilization in Italy after the introduction of a new lawFertility and Sterility, 2008
- How Does the Pre-Massage and Post-Massage 2-Glass Test Compare to the Meares-Stamey 4-Glass Test in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome?Journal of Urology, 2006
- Analysis of Outcomes of Cryopreserved Surgically Retrieved Sperm for IVF/ICSIJournal of Andrology, 2006
- Clinical management of men producing ejaculates characterized by high levels of dead sperm and altered seminal plasma factors consistent with epididymal necrospermiaFertility and Sterility, 2004
- Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyteThe Lancet, 1992