Pathological determinants of survival in node-negative oesophageal cancer
- 25 October 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 91 (12), 1586-1591
- https://doi.org/10.1002/bjs.4778
Abstract
Background Many studies have analysed prognostic factors following oesophagectomy, but few have examined survival determinants in node-negative (N0) oesophageal cancer. The prognostic significance of a number of histological variables following surgical resection of N0 oesophageal cancer was studied. Methods The case notes of 219 patients undergoing potentially curative oesophagectomy for N0 squamous cell carcinoma or adenocarcinoma of the oesophagus were reviewed. Details of the patient's sex, age at operation, histological type, longitudinal tumour length, tumour (T) stage, circumferential resection margin involvement, tumour grade, presence of vascular invasion, perineural invasion, Barrett's metaplasia, and survival were noted. Univariate and multivariate analyses were performed to identify prognostic factors. Results Univariate analysis revealed three factors that correlated with poor prognosis: T stage (P = 0·024), adenocarcinoma (P = 0·033) and degree of differentiation (P = 0·001). Multivariate analysis revealed that all three were significant independent adverse prognostic indicators. Conclusion Surgical resection of node-negative oesophageal cancer is associated with diverse long-term outcomes. This diversity of outcome is not reflected in the tumour node metastasis (TNM)-based staging system. The utility of the TNM system in predicting prognosis after surgical resection is open to question.Keywords
This publication has 24 references indexed in Scilit:
- Prognosis of Patients with T2N0 Tumors in the Alimentary Tract: Should They Be Considered as Early Cancers?Digestion, 2002
- Clinical implications of lymph node micrometastasis in patients with histologically node‐negative (pN0) esophageal carcinomaJournal of Surgical Oncology, 2002
- Clinical significance of lymph node micrometastasis of pN0 esophageal squamous cell carcinomaCancer Letters, 2000
- Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biologyBritish Journal of Cancer, 1999
- Standard Resection for Cancer of the Esophagus and CardiaSurgical Oncology Clinics of North America, 1999
- Changing patterns in the incidence of esophageal and gastric carcinoma in the United StatesCancer, 1998
- Surgery for esophageal cancer in elderly patients: The view from NottinghamThe Journal of Thoracic and Cardiovascular Surgery, 1998
- Prognostic Factors in Esophageal CancerSurgical Oncology Clinics of North America, 1997
- Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancerCancer, 1991
- Squamous carcinoma of the oesophagus: histological criteria and their prognostic significanceBritish Journal of Cancer, 1989