Male mice with deleted Wolframin (Wfs1) gene have reduced fertility
Open Access
- 10 August 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Reproductive Biology and Endocrinology
- Vol. 7 (1), 82
- https://doi.org/10.1186/1477-7827-7-82
Abstract
Wolfram Syndrome (WS) is an autosomal recessive disorder characterised by non-autoimmune diabetes mellitus, optic atrophy, cranial diabetes insipidus and sensorineural deafness. Some reports have described hypogonadism in male WS patients. The aim of our study was to find out whether Wfs1 deficient (Wfs1KO) male mice have reduced fertility and, if so, to examine possible causes.Keywords
This publication has 19 references indexed in Scilit:
- Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathwayPhysiological Genomics, 2009
- Wfs1-deficient mice display impaired behavioural adaptation in stressful environmentBehavioural Brain Research, 2009
- Common variants in WFS1 confer risk of type 2 diabetesNature Genetics, 2007
- Interpretation of knockout experiments: the congenic footprintGenes, Brain and Behavior, 2007
- WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cellsHuman Molecular Genetics, 2006
- WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-CellsJournal of Biological Chemistry, 2005
- Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activationActa Endocrinologica, 2005
- Diabetes Mellitus and Optic Atrophy: A Study of Wolfram Syndrome in the Lebanese PopulationJournal of Clinical Endocrinology & Metabolism, 2004
- Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretionHuman Molecular Genetics, 2004
- Psychiatric findings in Wolfram syndrome homozygotesThe Lancet, 1990