Effect of Withania Somnifera On Cytokine Production in Nol and Cyclophosphamide Treated Mice
- 1 January 1999
- journal article
- research article
- Published by Taylor & Francis Ltd in Immunopharmacology and Immunotoxicology
- Vol. 21 (4), 695-703
- https://doi.org/10.3109/08923979909007135
Abstract
Administration of an extract from the powdered root of the plant Withania somnifera(Family: Solanaceae) enhanced the levels of Interferon gamma (IFN -y> (75.87pg/ml), Interleukin-2 (IL-2) (14.16pg/ml) and Granulocyte macrophage colony stimulating factor (GM - CSF) (49.22pg/ml) in normal Balb/c mice. The lowered levels of IFN y - (30pg/ml), IL-2 (4.5pg/ml) and GM - CSF (19.12pg/ml) after treatment with cyclophosphamide (CTX) was reversed by the administration of Withania somnifera extract (IFN y - 74pg/ml; IL -27.5 pg/ml; GM - CSF 35.47pg/ml). Withania extract lowered the levels of Tumour necrosie factor alpha (TNFα) production. Administration of bonemarrow cells from donor mice treated with Withania extract increased the spleen nodular colonies in irradiated mice (8.33) compared to those treated with normal bonemarrow cells (3.03). The number of nodular colonies increased significantly when these animals were continued with Withania extract treatment. These results indicate the immunopotentiating and myeloprotective effect of Withania somnifera as seen from the enhancement of cytokine production and stem cell proliferation and its differentiation.This publication has 9 references indexed in Scilit:
- Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in miceJournal of Ethnopharmacology, 1998
- Cytokine Gene Therapy for Human TumorsSurgical Oncology Clinics of North America, 1998
- Anti-granuloma activity of Iraqi Withania somniferaJournal of Ethnopharmacology, 1992
- Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the UrotheliumThe New England Journal of Medicine, 1988
- Shock and Tissue Injury Induced by Recombinant Human CachectinScience, 1986
- A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating LymphocytesScience, 1986
- Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of EndotoxinScience, 1985
- Effect of withaferin a on ehrlich ascites tumor cells — cytological observationsInternational Journal of Cancer, 1970
- Constituents of Withania somnifera Dun. III. The Side Chain of Withaferin A*,1The Journal of Organic Chemistry, 1965