Activity of Pyocin S2 against Pseudomonas aeruginosa Biofilms
Open Access
- 1 March 2012
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 56 (3), 1599-1601
- https://doi.org/10.1128/aac.05714-11
Abstract
In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo .Keywords
This publication has 13 references indexed in Scilit:
- Swimming against the tide: progress and challenges in our understanding of colicin translocationNature Reviews Microbiology, 2010
- Inhaled aztreonamNature Reviews Drug Discovery, 2010
- Pyocin S2 (Sa) Kills Pseudomonas aeruginosa Strains via the FpvA Type I Ferripyoverdine ReceptorJournal of Bacteriology, 2007
- Pseudomonas aeruginosa chronic colonization in cystic fibrosis patientsCurrent Opinion in Pediatrics, 2007
- Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9Proceedings of the National Academy of Sciences of the United States of America, 2006
- Factors Associated with Relative Rates of Antibiotic Resistance in Pseudomonas aeruginosa Isolates Tested in Clinical Laboratories in the United States from 1999 to 2002Antimicrobial Agents and Chemotherapy, 2004
- A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistanceNature, 2003
- Use of the Galleria mellonella Caterpillar as a Model Host To Study the Role of the Type III Secretion System in Pseudomonas aeruginosa PathogenesisInfection and Immunity, 2003
- Lung Infections Associated with Cystic FibrosisClinical Microbiology Reviews, 2002
- Bacteria killing their own kind: novel bacteriocins of Pseudomonas and other γ-proteobacteriaTrends in Microbiology, 2002