NOX Enzymes in the Central Nervous System: From Signaling to Disease
- 1 October 2009
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 11 (10), 2481-2504
- https://doi.org/10.1089/ars.2009.2578
Abstract
Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen consumption, low antioxidant defense, and an abundance of oxidation-sensitive lipids. Production of reactive oxygen species (ROS) by mitochondria is generally thought to be the main cause of oxidative stress. However, a role for ROS-generating NADPH oxidase NOX enzymes has recently emerged. Activation of the phagocyte NADPH oxidase NOX2 has been studied mainly in microglia, where it plays a role in inflammation, but may also contribute to neuronal death in pathologic conditions. However, NOX-dependent ROS production can be due to the expression of other NOX isoforms, which are detected not only in microglia, but also in astrocytes and neurons. The physiologic and pathophysiologic roles of such NOX enzymes are only partially understood. In this review, we summarize the present knowledge about NOX enzymes in the central nervous system and their involvement in neurologic and psychiatric diseasesKeywords
This publication has 273 references indexed in Scilit:
- Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activationFree Radical Biology & Medicine, 2009
- The intimate and mysterious relationship between proton channels and NADPH oxidaseFEBS Letters, 2008
- Mechanism of alcohol-induced oxidative stress and neuronal injuryFree Radical Biology & Medicine, 2008
- Amyloid-β peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008
- The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosisAnnals of Neurology, 2008
- Voltage-gated proton channelsCellular and Molecular Life Sciences, 2008
- Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROSFree Radical Biology & Medicine, 2007
- Cytotoxicity of paraquat in microglial cells: Involvement of PKCδ- and ERK1/2-dependent NADPH oxidaseBrain Research, 2007
- Changes in the subcellular distribution of NADPH oxidase subunit p47phox in dendrites of rat dorsomedial nucleus tractus solitarius neurons in response to chronic administration of hypertensive agentsExperimental Neurology, 2007
- Reactive oxygen species modulate the differentiation of neurons in clonal cortical culturesMolecular and Cellular Neuroscience, 2006