Tandem Diels−Alder/Fragmentation Approach to the Synthesis of Eleutherobin
- 1 May 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (10), 1805-1808
- https://doi.org/10.1021/ol0345226
Abstract
A synthesis of 28, the carbon framework of the eleutherobin aglycone, is reported in a 15-step sequence from readily available starting materials. The tandem Diels-Alder reaction of 6 and 7 to produce 18, in which three new rings and six new stereocenters are formed, is a key step in the reaction sequence.Keywords
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