Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep
- 13 September 2011
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 108 (37), 15438-15443
- https://doi.org/10.1073/pnas.1112503108
Abstract
Humans are less responsive to the surrounding environment during sleep. However, the extent to which the human brain responds to external stimuli during sleep is uncertain. We used simultaneous EEG and functional MRI to characterize brain responses to tones during wakefulness and non-rapid eye movement (NREM) sleep. Sounds during wakefulness elicited responses in the thalamus and primary auditory cortex. These responses persisted in NREM sleep, except throughout spindles, during which they became less consistent. When sounds induced a K complex, activity in the auditory cortex was enhanced and responses in distant frontal areas were elicited, similar to the stereotypical pattern associated with slow oscillations. These data show that sound processing during NREM sleep is constrained by fundamental brain oscillatory modes (slow oscillations and spindles), which result in a complex interplay between spontaneous and induced brain activity. The distortion of sensory information at the thalamic level, especially during spindles, functionally isolates the cortex from the environment and might provide unique conditions favorable for off-line memory processing.Keywords
This publication has 40 references indexed in Scilit:
- Source modeling sleep slow wavesProceedings of the National Academy of Sciences of the United States of America, 2009
- Spontaneous neural activity during human slow wave sleepProceedings of the National Academy of Sciences of the United States of America, 2008
- The use of evoked potentials in sleep researchSleep Medicine Reviews, 2007
- Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleepProceedings of the National Academy of Sciences of the United States of America, 2007
- Triggering sleep slow waves by transcranial magnetic stimulationProceedings of the National Academy of Sciences of the United States of America, 2007
- ICA-based procedures for removing ballistocardiogram artifacts from EEG data acquired in the MRI scannerNeuroImage, 2005
- Functional anatomy of pitch memory—an fMRI study with sparse temporal samplingNeuroImage, 2003
- Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standardPsychiatry and Clinical Neurosciences, 2001
- Event‐related potentials to tones in the absence and presence of sleep spindlesJournal of Sleep Research, 1997
- Thalamocortical Oscillations in the Sleeping and Aroused BrainScience, 1993