Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes

Abstract

The authors report that the spiking history of small, randomly sampled ensembles of human and nonhuman primate cortical neurons can predict subsequent single neuron spiking. Spiking could be predicted by both local ensemble spiking histories as well as those in other cortical areas. These results provide evidence for strong collective cortical dynamics at the level of neuronal spikes. Coordinated spiking activity in neuronal ensembles, in local networks and across multiple cortical areas, is thought to provide the neural basis for cognition and adaptive behavior. Examining such collective dynamics at the level of single neuron spikes has remained, however, a considerable challenge. We found that the spiking history of small and randomly sampled ensembles (∼20−200 neurons) could predict subsequent single neuron spiking with substantial accuracy in the sensorimotor cortex of humans and nonhuman behaving primates. Furthermore, spiking was better predicted by the ensemble's history than by the ensemble's instantaneous state (Ising models), emphasizing the role of temporal dynamics leading to spiking. Notably, spiking could be predicted not only by local ensemble spiking histories, but also by spiking histories in different cortical areas. These strong collective dynamics may provide a basis for understanding cognition and adaptive behavior at the level of coordinated spiking in cortical networks.