Surgical Approaches to Create Murine Models of Human Wound Healing
Top Cited Papers
Open Access
- 1 January 2011
- journal article
- review article
- Published by Hindawi Limited in Journal of Biomedicine and Biotechnology
- Vol. 2011, 1-8
- https://doi.org/10.1155/2011/969618
Abstract
Wound repair is a complex biologic process which becomes abnormal in numerous disease states. Althoughin vitromodels have been important in identifying critical repair pathways in specific cell populations,in vivomodels are necessary to obtain a more comprehensive and pertinent understanding of human wound healing. The laboratory mouse has long been the most common animal research tool and numerous transgenic strains and models have been developed to help researchers study the molecular pathways involved in wound repair and regeneration. This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.Keywords
Funding Information
- National Institutes of Health (R01EB-005718, R01/R56DK-074095, W81XWH-08-2-0032)
This publication has 74 references indexed in Scilit:
- Embolus extravasation is an alternative mechanism for cerebral microvascular recanalizationNature, 2010
- Aging and Diabetes Impair the Neovascular Potential of Adipose-Derived Stromal CellsPlastic and Reconstructive Surgery, 2009
- Mesenchymal Stem Cells Can Participate in Ischemic NeovascularizationPlastic and Reconstructive Surgery, 2009
- Three‐Dimensional Tissue Models of Normal and Diseased SkinCurrent Protocols in Cell Biology, 2008
- Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cellsJournal of Cellular Physiology, 2008
- Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic MicePublished by Elsevier BV ,2008
- Cellular and molecular mechanisms of fibrosisThe Journal of Pathology, 2007
- Intravital insights in skin wound healing using the mouse dorsal skin fold chamberJournal of Anatomy, 2007
- Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarringWound Repair and Regeneration, 2007
- Histology of the thick scar on the female, red Duroc pig: Final similarities to human hypertrophic scarBurns, 2006