New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling
- 7 May 2013
- journal article
- research article
- Published by Elsevier BV in Journal of Molecular and Cellular Cardiology
- Vol. 62, 80-89
- https://doi.org/10.1016/j.yjmcc.2013.04.026
Abstract
No abstract availableFunding Information
- National Institute on Aging
- National Institutes of Health
This publication has 26 references indexed in Scilit:
- The “Funny” Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker CellsMolecules, 2012
- Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca2+ Cycling Modulates Cardiac Pacemaker Cell AutomaticityPLOS ONE, 2012
- Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in miceJCI Insight, 2010
- Sarcoplasmic Reticulum Ca 2+ Pumping Kinetics Regulates Timing of Local Ca 2+ Releases and Spontaneous Beating Rate of Rabbit Sinoatrial Node Pacemaker CellsCirculation Research, 2010
- If and SR Ca2+ release both contribute to pacemaker activity in canine sinoatrial node cellsJournal of Molecular and Cellular Cardiology, 2010
- A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteinsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2010
- A Coupled SYSTEM of Intracellular Ca2+Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s PacemakerCirculation Research, 2010
- What is the purpose of the large sarcolemmal calcium flux on each heartbeat?American Journal of Physiology-Heart and Circulatory Physiology, 2009
- Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditionsCardiovascular Research, 2005
- Current-dependent Block of Rabbit Sino-Atrial Node If Channels by IvabradineThe Journal of general physiology, 2002