Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
Open Access
- 1 December 2004
- journal article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 10 (12), 2221-2224
- https://doi.org/10.3201/eid1012.040647
Abstract
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.Keywords
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