Estimating the probability of toxicity at the target dose following an up‐and‐down design
- 28 January 2003
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 22 (4), 535-543
- https://doi.org/10.1002/sim.1351
Abstract
One of the most important aspects of a phase I trial or other acute toxicity study is estimating accurately the probability of toxicity that is associated with the recommended dose. We use the biased coin up-and-down design to allocate and isotonic regression to estimate toxicity probabilities and determine the recommended dose. We then derive, using bootstrap methods, an estimate of the probability of toxicity at the recommended dose. Small sample properties of this estimator are also evaluated. Published in 2003 by John Wiley & Sons, Ltd.Keywords
This publication has 13 references indexed in Scilit:
- Dose Finding Using the Biased Coin Up‐and‐Down Design and Isotonic RegressionBiometrics, 2002
- A Random Walk Rule for Phase I Clinical TrialsBiometrics, 1997
- Continual Reassessment Method: A Likelihood ApproachBiometrics, 1996
- Some practical improvements in the continual reassessment method for phase I studiesStatistics in Medicine, 1995
- A comparison of two phase I trial designsStatistics in Medicine, 1994
- Small-Sample Confidence Sets for the MTD in a Phase I Clinical TrialBiometrics, 1993
- Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in CancerBiometrics, 1990