THE GEOGRAPHICAL DISTRIBUTION OF THYROTOXICOSIS IN ENGLAND ACCORDING TO THE PRESENCE OR ABSENCE OF TSH‐RECEPTOR ANTIBODIES
- 1 September 1985
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 23 (3), 283-287
- https://doi.org/10.1111/j.1365-2265.1985.tb00225.x
Abstract
In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH‐receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r= 0·9) indicating a high current incidence of toxic nodular goitre in previously goitrous towns. Antibody positive thyrotoxicosis, an indicator of Graves’ disease, showed no correlation with goitre although there was statistically significant geographical variation in incidence. The percentage of all thyrotoxic patients who were antibody positive varied between towns, from 35% to 92%.Keywords
This publication has 8 references indexed in Scilit:
- CURRENT INCIDENCE OF THYROTOXICOSIS AND PAST PREVALENCE OF GOITRE IN 12 BRITISH TOWNSThe Lancet, 1984
- A RECEPTOR ASSAY FOR THE MEASUREMENT OF TSH RECEPTOR ANTIBODIES IN UNEXTRACTED SERUMClinical Endocrinology, 1984
- An enzyme-linked immunoassay for thyroid microsomal antibodiesJournal of Immunological Methods, 1982
- Hyperthyroidism in Tasmania Following Iodide Supplementation: Measurements of Thyroid-Stimulating Autoantibodies and ThyrotropinJournal of Clinical Endocrinology & Metabolism, 1975
- A Study of Graves' Disease in IcelandActa Medica Scandinavica, 1975
- Aetiology of hyperthyroidism. I.BMJ, 1974
- Goitre in the English School ChildQJM: An International Journal of Medicine, 1928