25-Hydroxycholecalciferol to 1,25-Dihydroxycholecalciferol: Conversion Impaired by Systemic Metabolic Acidosis
- 11 March 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4282), 994-996
- https://doi.org/10.1126/science.841324
Abstract
An acute systemic acidosis in vitamin D depleted rats that was induced by ammonium chlroide feeding resulted in defective biological hydroxylation of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. Impaired enzymatic hydroxylation occurred despite the presence of either hypophosphatemia or hypocalcemia. The data suggest that acidosis interfers with the adaptive enzymatic control of 25-hydroxycholecalciferol metabolism in the vitamin D depleted state.This publication has 22 references indexed in Scilit:
- EFFECT OF CALCIUM DEPRIVATION ON PARATHYROID HORMONE-MEDIATED BONE AND KIDNEY CONTRIBUTIONS TO THE MAINTENANCE OF PLASMA CALCIUM IN RATSJournal of Endocrinology, 1975
- The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion.JCI Insight, 1975
- The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules.JCI Insight, 1975
- The influence of dietary calcium and phosphorus on intestinal calcium transport in rats given vitamin D metabolitesArchives of Biochemistry and Biophysics, 1975
- The control of 25-hydroxyvitamin D metabolism by inorganic phosphorusArchives of Biochemistry and Biophysics, 1973
- TREATMENT OF OSTEOMALACIA OF RENAL TUBULAR ACIDOSIS BY SODIUM BICARBONATE ALONEThe Lancet, 1972
- Vitamin D, the kidney and calcium homeostasisKidney International, 1972
- The metabolic fate of vitamin D3-3H in chronic renal failureJCI Insight, 1968
- Metabolic balance studies in primary renal tubular acidosis: Effects of acidosis on external calcium and phosphorus balancesThe Journal of Pediatrics, 1966
- THE VARIOUS ETIOLOGIES MET IN THE UNITED STATES WITH EMPHASIS ON THAT RESULTING FROM A SPECIFIC FORM OF RENAL ACIDOSIS, THE THERAPEUTIC INDICATIONS FOR EACH ETIOLOGICAL SUB-GROUP, AND THE RELATIONSHIP BETWEEN OSTEOMALACIA AND MILKMANʼS SYNDROMEMedicine, 1946