Boric Acid Disturbs Cell Wall Synthesis inSaccharomyces cerevisiae
Open Access
- 27 December 2010
- journal article
- research article
- Published by Hindawi Limited in International Journal of Microbiology
- Vol. 2010, 1-10
- https://doi.org/10.1155/2010/930465
Abstract
Boric acid (BA) has broad antimicrobial activity that makes it a popular treatment for yeast vaginitis in complementary and alternative medicine. In the model yeastS. cerevisiae, BA disturbs the cytoskeleton at the bud neck and impairs the assembly of the septation apparatus. BA treatment causes cells to form irregular septa and leads to the synthesis of irregular cell wall protuberances that extend far into the cytoplasm. The thick, chitin-rich septa that are formed during BA exposure prevent separation of cells after abscission and cause the formation of cell chains and clumps. As a response to the BA insult, cells signal cell wall stress through the Slt2p pathway and increase chitin synthesis, presumably to repair cell wall damage.Keywords
Funding Information
- Iowa Osteopathic Education and Research Foundation
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