Peptide-binding specificity of the molecular chaperone BiP
- 1 October 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 353 (6346), 726-730
- https://doi.org/10.1038/353726a0
Abstract
Members of the heat-shock protein family (hsp70s) can distinguish folded from unfolded proteins. This property is crucial to the role of hsp70s as molecular chaperones and is attributable to the amino-acid specificity of the peptide-binding site. The specificity for peptide ligands is investigated using a set of peptides of random sequence but defined chain length. The peptide-binding site selects for aliphatic residues and accommodates them in an environment energetically equivalent to the interior of a folded protein.Keywords
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