The Distribution of Fasting Plasma Lipid Concentrations in the Offspring of Men with Premature Coronary Heart Disease in Europe. The EARS Study

Abstract

Fasting plasma total holesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and total triglyceride was measured In 682 unIversity students with a positive paternal history of coronary heart disease before the age of 55 years and 1312 age- and sex-matched controls recruited from 14 European centres. In male subjects, significant regional differences were observed for triglyceride (P< 0.005) and HDL-cholesterol (P< 0.05) but not for total or LDL-cholesterol. In female subjects, significant regional differences were observed for triglyceride (P< 0.05) and cholesterol (P < 0.05) but not for HDL- or LDL-cholesterol. Significant differences were observed between male cases and controls for cholesterol (P < 0.005) LDL-cholesterol (P < 0.005) and triglycerides (P < 0.005) but not for HDL-cholesterol. In females a significant difference was observed between cases and controls for LDL-cholesterol (P < 0.05) but not for total cholesterol, HDL-cholesterol or triglyceride.