Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

Abstract

Summary: Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin‐10 (IL‐10) participates in an ever‐increasing diversity of T‐cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL‐10 produced by distinct CD4⁺ T‐cell lineages that underlie its non‐redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T‐cell‐driven inflammation in responses to pathogens.