Lignans and Other Constituents of the Fruits of Euterpe oleracea (Açai) with Antioxidant and Cytoprotective Activities
- 26 July 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 56 (17), 7759-7764
- https://doi.org/10.1021/jf801792n
Abstract
Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active in an in vitro hydroxyl radical scavenging assay and seven of these isolates in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.Keywords
This publication has 58 references indexed in Scilit:
- Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)Phytotherapy Research, 2008
- Phytochemical and Nutrient Composition of the Freeze-Dried Amazonian Palm Berry, Euterpe oleraceae Mart. (Acai)Journal of Agricultural and Food Chemistry, 2006
- Knotwood and bark extracts: strong antioxidants from waste materialsJournal of Wood Science, 2006
- Hepatoprotective activity of Schouwia thebica webbBioorganic & Medicinal Chemistry Letters, 2006
- Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia CellsJournal of Agricultural and Food Chemistry, 2006
- Evaluation of the Antioxidant Capacity of Individual Phenolic Compounds in Virgin Olive OilJournal of Agricultural and Food Chemistry, 2005
- Total oxidant scavenging capacities ofEuterpe oleraceaMart. (Açaí) fruitsInternational Journal of Food Sciences and Nutrition, 2005
- Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leavesLife Sciences, 2004
- New Colorimetric Cytotoxicity Assay for Anticancer-Drug ScreeningJNCI Journal of the National Cancer Institute, 1990
- Heterocycles. XXII. Stereoselective synthesis of (+)-aromadendrin trimethyl ether and its enantiomer, and their reduction.CHEMICAL & PHARMACEUTICAL BULLETIN, 1988