Candida glabrata endophthalmitis following penetrating keratoplasty

Abstract

A 43 year old man with keratoconus had two previous right corneal grafts. The first, in 1974, became vascularised and oedematous after several months; the second, in 1990, failed after two rejection episodes. In February 1995 he underwent further right penetrating keratoplasty using tissue typed material, stored in organ culture for 20 days and transport medium (5% dextran) for 2 days. On the first postoperative day UK Transplant Support Service Authority reported culture of a yeast from the transport medium, subsequently identified as Candida glabrata. Clinically the graft was satisfactory but topical econozole 1% (in arachis oil) was given prophylactically six times daily.