Gamma‐glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer
- 26 April 2013
- journal article
- research article
- Published by Wiley in Colorectal Disease
- Vol. 15 (8), e443-e452
- https://doi.org/10.1111/codi.12258
Abstract
Aim Biomarkers have been utilized for prognosis in colorectal cancer; however, relatively few have been identified. We compared the prognostic value of serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma‐glutamyl transpeptidase (GGT) with carcinoembryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) in patients with metastatic colorectal cancer (mCRC). Method Blood samples were collected from 239 patients with mCRC presenting between 2005 and 2010 in the Sun Yat‐sen University Cancer Center. Results CEA (P < 0.001), CA19‐9 (P < 0.001), GGT (P < 0.001), ALP (P < 0.001) and LDH (P = 0.001) were statistically significant prognostic factors of overall survival (OS). CEA (P = 0.002) and GGT (P = 0.021) were validated as independent predictors. On univariate analysis, CEA (P = 0.003), CA19‐9 (P = 0.006), GGT (P < 0.001) and ALP (P = 0.001) were statistically significant predictive factors of progression‐free survival (PFS) in patients having first‐line chemotherapy. CEA (P = 0.011) and GGT (P = 0.027) were independent predictors. GGT (P = 0.001), ALP (P = 0.016) and LDH (P = 0.039) levels were correlated with the tumour response rate assessed by CT, whilst CEA (P = 0.724) and CA19‐9 (P = 0.822) were not. There was a statistically significant difference in OS (P < 0.001) and PFS (P < 0.001) among patients who had elevations of both CEA and GGT compared with those in whom only one or neither was elevated. Conclusion Among GGT, LDH and ALP, only GGT plays an independent role with CEA in predicting OS and PFS in mCRC. When coupled with CEA, GGT may lead to improved prognostic predictors.Keywords
This publication has 30 references indexed in Scilit:
- Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinomaChinese Journal of Cancer, 2012
- Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation TherapyBMC Cancer, 2012
- Correlation between TBARS levels and glycolytic enzymes: The importance to the initial evaluation of clinical outcome of colorectal cancer patientsBiomedicine & Pharmacotherapy, 2011
- Biomarkers of alcohol consumption and related liver diseaseScandinavian Journal of Clinical and Laboratory Investigation, 2010
- FOLFOX in patients with metastatic colorectal cancer and high alkaline phosphatase level: an exploratory cohort of the GERCOR OPTIMOX1 studyAnnals Of Oncology, 2009
- LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancerMolecular Cancer Therapeutics, 2009
- γ-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liverHepatology, 2002
- Microglial cells induce cytotoxic effects toward colon carcinoma cells: Measurement of tumor cytotoxicity with a ?-glutamyl transpeptidase assayInternational Journal of Cancer, 1997
- Cisplatin and 5-fluorouracil infusion for metastatic colorectal carcinoma. Differences in survival in two patient groups with similar response ratesCancer, 1989
- γ -Glutamyltranspeptidase activity in human breast lesions: An unfavourable prognostic signBritish Journal of Cancer, 1986