Local Control of Vascular Resistance
- 1 June 1974
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 133 (6), 916-931
- https://doi.org/10.1001/archinte.1974.00320180034003
Abstract
Cations are involved in the entire sequence of normal tension development in both cardiac and vascular smooth muscle. Sodium is also a determinant of blood volume and consequently of filling pressure of the right side of the heart. It is, therefore, not surprising that diseases that affect the usual extracellular and intracellular concentrations of cations also affect blood pressure. In this review, emphasis is placed on the roles of cations and water in the genesis of the hypertension seen in association with excessive salt intake, malfunction of the adrenal cortex and kidney, and hypercalcemic states. Related literature in the basic sciences is summarized in the context of both experimental and clinical hypertension. Areas in need of additional exploration are also pointed out.Keywords
This publication has 66 references indexed in Scilit:
- Predicting transient and steady-state changes in resting membrane potential.Journal of Applied Physiology, 1973
- Electrogenic sodium pump in nerve and muscle cells.Physiological Reviews, 1972
- The Myocardial Cell: New Concepts for the Clinical CardiologistCirculation, 1972
- Excitation—contraction coupling in frog ventricle: evidence from voltage clamp studiesThe Journal of Physiology, 1971
- Inotropic Effects of Electric CurrentsCirculation Research, 1969
- Metabolically linked vasoactive chemicals in local regulation of blood flow.Physiological Reviews, 1968
- Ion fluxes in cardiac excitation and contraction and their relation to myocardial contractility.Physiological Reviews, 1968
- MEMBRANE ADENOSINE TRIPHOSPHATASE AND CATION TRANSPORTBritish Medical Bulletin, 1968
- Relaxing factor and the relaxation of muscleProgress in Biophysics and Molecular Biology, 1964
- Excitation and Excitatin-Contraction Coupling in Cardiac MuscleAnnual Review of Physiology, 1964