Therapeutic gene causing lymphoma
- 26 April 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 440 (7088), 1123
- https://doi.org/10.1038/4401123a
Abstract
The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells1 has led to a re-evaluation of this approach2. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected. Gene-therapy trials for X-SCID, which have been based on the assumption that IL2RG is minimally oncogenic3,4,5,6,7, may therefore pose some risk to patients.Keywords
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