Polyhedral Boron Compounds as Potential Linkers for Attachment of Radiohalogens to Targeting Proteins and Peptides. A Review
- 1 January 2002
- journal article
- review article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 67 (7), 913-935
- https://doi.org/10.1135/cccc20020913
Abstract
Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.Keywords
This publication has 54 references indexed in Scilit:
- PET imaging in oncologySeminars in Nuclear Medicine, 2000
- Radioimmunoimaging and radioimmunotherapy: Will these be routine procedures?Seminars in Nuclear Medicine, 2000
- Radio-labeled receptor-binding peptides: A new class of radiopharmaceuticalsSeminars in Nuclear Medicine, 2000
- Applications of Radiolabeled Boron Clusters to the Diagnosis and Treatment of CancerChemical Reviews, 1999
- Therapeutic RadiopharmaceuticalsChemical Reviews, 1999
- Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazoleNuclear Medicine and Biology, 1994
- Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labelingBioconjugate Chemistry, 1992
- A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodineInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1987
- Synthesis and antibody-labeling studies with the p-isothiocyanatobenzene derivatives of 1,2-dicarba-closo-dodecarborane(12) and the dodecahydro-7,8-dicarbanido-undecaborate(-1) ion for neutron-capture therapy of human cancer. Crystal and molecular structure of Cs+[nido-7-(p-C6H4NCS)-9-I-7,8-C2B9H11]-Inorganic Chemistry, 1985
- RADIOLABELING OF MONOCLONAL AMTITUMOR ANTIBODIESClinical Nuclear Medicine, 1981