Oligonucleotide‐Based Mimetics of Hepatocyte Growth Factor
- 23 November 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 55 (2), 579-582
- https://doi.org/10.1002/anie.201508572
Abstract
Oligonucleotide-based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss-0, which was composed solely of 100-mer single-stranded DNA, exhibited nanomolar potency. Aptamer ss-0 reproduced HGF-induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics.Funding Information
- Japan Science and Technology Agency
- Japan Society for the Promotion of Science
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