Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
- 19 May 2016
- journal article
- research article
- Published by Elsevier BV in Cell Metabolism
- Vol. 23 (6), 1140-1153
- https://doi.org/10.1016/j.cmet.2016.04.016
Abstract
No abstract availableKeywords
Funding Information
- US National Institutes of Health (R01CA16359-01A1)
- Stand Up To Cancer (SU2C-AACR-DT0509)
- Brewster Foundation
- NIH (R01CA141062)
- US Department of Defense (BC123187)
- American Cancer Society (PF-15-190-01- TBE)
- NJCCR postdoctoral fellowship (DFHS15PPC044)
- NIH (F31CA192461)
- PMU-FFF fellowship (L-15/03/004-MOR)
This publication has 39 references indexed in Scilit:
- Quantitative flux analysis reveals folate-dependent NADPH productionNature, 2014
- Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancerNature Communications, 2014
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing SpecificityCell, 2013
- Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMolecular Systems Biology, 2013
- Functional genomics reveal that the serine synthesis pathway is essential in breast cancerNature, 2011
- Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult TissuesPublished by Elsevier BV ,2011
- Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primatesToxicology and Applied Pharmacology, 2010
- Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in EmbryosPublished by Elsevier BV ,2010
- The Role of Serine Hydroxymethyltransferase Isozymes in One-Carbon Metabolism in MCF-7 Cells as Determined by 13C NMRArchives of Biochemistry and Biophysics, 2001
- Binding and interconversion of tetrahydrofolates at a single site in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolaseBiochemistry, 1995