Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy

Open Access

Abstract

Mood and anxiety symptoms in chronic hepatitis C (CHC) may be related to the patient awareness of the diagnosis and prognosis, to side effects induced by interferon (IFN)-alpha treatment, as well as to substance abuse. However, the observation of metabolic alterations in patients with CHC has led to hypothesize a direct effect of hepatitis C virus (HCV) on brain function. This study was aimed at elucidating whether CHC is associated with specific anxiety or mood disorders independently of confounding factors.

Keywords

This publication has 21 references indexed in Scilit:

Interferon-α-Induced Depression: When a Randomized Trial Is Not a Randomized Controlled Trial
Psychotherapy and Psychosomatics, 2005
Hepatitis B virus infection among inpatients of a psychiatric hospital of Mexico
Clinical Practice and Epidemiology in Mental Health, 2005
Emotional Stress, Psychosocial Variables and Coping Associated with Hepatitis C Virus and Human Immunodeficiency Virus Infections in Intravenous Drug Users
Psychotherapy and Psychosomatics, 2002
Emotional distress in chronic hepatitis C patients not receiving antiviral therapy
Journal of Hepatology, 2002
Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease
Hepatology, 2002
Evidence for a cerebral effect of the hepatitis C virus
The Lancet, 2001
Comorbidities and quality of life in patients with interferon-refractory chronic hepatitis C
The American Journal of Gastroenterology, 2001
Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy
Hepatology, 1999
Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis
Hepatology, 1998
On Transference in the Treatment of Organic Diseases
Psychotherapy and Psychosomatics, 1979

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