Low Testosterone and the Association With Type 2 Diabetes
- 1 September 2008
- journal article
- research article
- Published by SAGE Publications in The Diabetes Educator
- Vol. 34 (5), 799-806
- https://doi.org/10.1177/0145721708323100
Abstract
Purpose The purpose of this article is to describe androgen deficiency in men, the consequences of this clinically underdiagnosed endocrine disorder, and its relationship to the metabolic syndrome and the association with type 2 diabetes. An overview of prevalence, screening, diagnosis, treatment, and monitoring of male hypogonadism is presented. Method Established guidelines were used to provide definition, diagnosis, treatment, and monitoring information for male hypogonadism. A literature review from 1990 to 2007 revealed study findings that identify the link between low testosterone in men and the development of type 2 diabetes. The following databases were used to review and analyze the current literature: CINAHL, PubMed, and MEDLINE. Results An analysis of 26 studies was completed. The key findings in all of these studies show that there is a link between low levels of testosterone and an adverse metabolic profile (ie, obesity and insulin resistance). There is evidence that hypogonadism is associated with metabolic syndrome and type 2 diabetes in men. Conclusion Male hypogonadism is a clinical condition that affects a significant number of men in the United States and can affect up to 50% of men diagnosed with type 2 diabetes. The implications for diabetes educators are two-fold: first, there is a high prevalence of low testosterone in men with type 2 diabetes, and second, educators need to have a better understanding of this disease state to provide instructional guidance for their patients and to coordinate care with other clinicians.Keywords
This publication has 24 references indexed in Scilit:
- Prevalence of hypogonadism in males aged at least 45 years: the HIM studyPublished by Hindawi Limited ,2008
- Impact of Recent Increase in Incidence on Future Diabetes BurdenDiabetes Care, 2006
- Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice GuidelineJournal of Clinical Endocrinology & Metabolism, 2006
- Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetesActa Endocrinologica, 2006
- Contrasting Testosterone Concentrations in Type 1 and Type 2 DiabetesDiabetes Care, 2006
- Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinicInternational Journal Of Impotence Research, 2005
- Increasing Insulin Resistance Is Associated with a Decrease in Leydig Cell Testosterone Secretion in MenJournal of Clinical Endocrinology & Metabolism, 2005
- Endogenous Sex Hormones and Metabolic Syndrome in Aging MenJournal of Clinical Endocrinology & Metabolism, 2005
- Androgens in Primary CarePublished by Springer Science and Business Media LLC ,2003
- Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.Diabetes Care, 2000