Anticarcinoma Activity in Vivo of Rhodamine 123, a Mitochondrial-Specific Dye
- 14 October 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4620), 169-172
- https://doi.org/10.1126/science.6623064
Abstract
Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.This publication has 6 references indexed in Scilit:
- Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in cultureInflammation Research, 1984
- Rhodamine-123 Selectively Reduces Clonal Growth of Carcinoma Cells in VitroScience, 1982
- Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy.The Journal of cell biology, 1981
- Cancer Statistics, 1981CA: A Cancer Journal for Clinicians, 1981
- Rhodamine 6G, inhibitor of both H+-ejections from mitochondria energized with ATP and with respiratory substratesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1980
- Rhodamine 6GJournal of Biological Chemistry, 1974