Organic reactions in low melting mixtures based on carbohydrates and l-carnitine—a comparison
- 24 March 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 11 (6), 848-854
- https://doi.org/10.1039/b816551c
Abstract
A new L-carnitine/urea melt was developed and compared to previously reported sugar and sugar alcohol melts using several organic reactions for benchmarking. Physicochemical properties of the new L-carnitine melt, including the melting point and the polarity were determined by differential scanning calorimetry (DSC) and solvatochromatic measurements, respectively. The L-carnitine melt shows a very high polarity. Heck and Sonogashira cross-couplings, Diels–Alder reactions and Cu-catalysed 1,3-dipolar cycloadditions proceed cleanly in sugar and L-carnitine based melts, but the applicability of L-carnitine melts for standard organic reactions is limited by their lower thermal stability.Keywords
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