Ablation vs Medical Therapy in the Setting of Symptomatic Atrial Fibrillation and Left Ventricular Dysfunction
- 13 January 2010
- journal article
- research article
- Published by Wiley in Congestive Heart Failure
- Vol. 16 (1), 10-14
- https://doi.org/10.1111/j.1751-7133.2009.00116.x
Abstract
Small, single-center studies suggest that catheter ablation of atrial fibrillation (AF) can improve ventricular function and reduce symptoms in patients with left ventricular (LV) dysfunction. However, ablation has not been compared with a pharmacologic strategy for AF. The authors evaluated patients with AF and symptomatic LV dysfunction (ejection fraction < or =45%) referred for pulmonary vein isolation (PVI). They compared these patients with a matched cohort treated medically for AF and LV dysfunction via a retrospective case-control method. Fifteen patients (14 men, 56+/-11 years, 10 [67%] paroxysmal AF) with AF for 4+/-3 years underwent PVI. Baseline ejection fraction was 37%+/-6% and New York Heart Association (NYHA) class was 2.0+/-1.0. Fifteen controls (13 men, 63+/-14 years, 11 [73%] paroxysmal AF) with AF for 5+/-4 years were treated medically for AF. Baseline ejection fraction was 34%+/-11% and NYHA class was 2.0+/-0.7. The groups were similar in all respects. During a follow-up of 16+/-13 months after complete PVI, ejection fraction improved (P=.001) to 50%+/-13% and normalized in 8 patients (53%). NYHA class improved to 1.3+/-0.5 (P=.01). In the medically treated group, after follow-up of 16+/-12 months, no improvement in ejection fraction (36%+/-12%) or NYHA class (1.8+/-0.7) was seen. Compared with pharmacologic therapy, PVI significantly improved LV function and NYHA class in patients with AF and symptomatic LV dysfunction. These provocative findings provide potent rationale for a randomized clinical trial comparing ablation with pharmacologic therapy.Keywords
This publication has 20 references indexed in Scilit:
- Pulmonary Vein Vestibule Ablation for the Control of Atrial Fibrillation in Patients with Impaired Left Ventricular FunctionPacing and Clinical Electrophysiology, 2006
- Atrial Fibrillation and Risk of Clinical Events in Chronic Heart Failure With and Without Left Ventricular Systolic Dysfunction: Results From the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) ProgramJournal of the American College of Cardiology, 2006
- Circumferential Pulmonary-Vein Ablation for Chronic Atrial FibrillationThe New England Journal of Medicine, 2006
- Atrial Fibrillation and Congestive Heart Failure: Risk Factors, Mechanisms, and TreatmentProgress in Cardiovascular Diseases, 2006
- Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: Results from the RAte Control versus Electrical cardioversion (RACE) studyAmerican Heart Journal, 2005
- Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial FibrillationJama-Journal Of The American Medical Association, 2005
- Anatomic substrate, procedural results, and clinical outcome of ultrasound-guided left atrial–pulmonary vein disconnection for treatment of atrial fibrillationThe American Journal of Cardiology, 2005
- Catheter Ablation for Atrial Fibrillation in Congestive Heart FailureThe New England Journal of Medicine, 2004
- Pulmonary vein isolation for the treatment of atrial fibrillation in patients with impaired systolic functionJournal of the American College of Cardiology, 2004
- Long-Term Follow-Up After Radiofrequency Modification of the Atrioventricular Node in Patients With Atrial FibrillationJournal of the American College of Cardiology, 1997