New Screen Printed Electrode Based on Graphite and Polyurethane Composite for the Determination of Acetaminophen
- 15 January 2013
- journal article
- research article
- Published by Informa UK Limited in Analytical Letters
- Vol. 46 (2), 312-322
- https://doi.org/10.1080/00032719.2012.718829
Abstract
A disposable screen-printed electrode based on a graphite and polyurethane resin composite (EIGPU) was developed and evaluated as a voltammetric detector in pharmaceutical analysis. Using cyclic voltammetry, an analytical curve was obtained with the linear dynamic range between 1.00–100 µmol L−1 and a detection limit of 8.18 × 10−7 mol L−1 for acetaminophen (paracetamol) as a probe. During the APAP determination in pharmaceutical formulations, recoveries between 97.2 and 102% were found. There were no interferences from ascorbic acid and other constituents of the pharmaceutical formulation at the 95% confidence level compared to HPLC analysis.Keywords
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