Tc‐99m‐HMPAO SPECT in the diagnosis of brain death in children
- 22 December 2004
- journal article
- research article
- Published by Wiley in Pediatrics International
- Vol. 46 (6), 711-714
- https://doi.org/10.1111/j.1442-200x.2004.01976.x
Abstract
The diagnosis of brain death is based on both clinical and laboratory findings. However, diagnosis of brain death is still contentious and reliable tests are required. Early recognition and declaration of the diagnosis is the main goal, which is important for discontinuation of life support and organ donation for transplantation. In order to achieve this goal, competent diagnostic procedures should be performed. In this paper the authors review the diagnosis of brain death in eight children from different age groups, with an emphasis on factors concerning the reliability, use and appropriate application time of Tc-99m-HMPAO single photon emission computed tomography (SPECT) in early diagnosis in infants and newborns. Eight patients who fulfilled the clinical criteria of brain death underwent Tc-99m HMPAO SPECT and electroencephalogram (EEG) monitoring. All patients had electrocerebral silence on EEG recordings. Six patients showed lack of perfusion in cerebrum in their first SPECT, however, newborns needed a second image for a confirmed diagnosis. In infants, SPECT has a high reliability for confirmed diagnosis of brain death; however, in newborns the application time is important for an accurate diagnosis.Keywords
This publication has 9 references indexed in Scilit:
- 99mTc-HMPAO SPECT in the diagnosis of brain deathIntensive Care Medicine, 1998
- Brain Death in the NewbornClinics in Perinatology, 1997
- 99mTc HM-PAO brain perfusion SPECT in brain deathNeuroradiology, 1995
- Guideline ThreeJournal of Clinical Neurophysiology, 1994
- Brain death: Determination with brain stem evoked potentials and radionuclide isotope studiesActa Neurochirurgica, 1991
- The Hollow Skull: A Sign of Brain Death in Tc-99m HM-PAO Brain ScintigraphyClinical Nuclear Medicine, 1989
- Determination of brain death in children with 123I-IMP and Tc-99m HMPAOPsychiatry Research, 1989
- Brain Death in the NewbornPEDIATRICS, 1989
- Guidelines for the Determination of Brain Death in ChildrenPEDIATRICS, 1987