Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer
Open Access
- 10 July 2014
- journal article
- Published by Walter de Gruyter GmbH in Radiology and Oncology
- Vol. 48 (3), 228-234
- https://doi.org/10.2478/raon-2013-0075
Abstract
Positron emission tomography-computed tomography (PET/CT) with 18F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases. In 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, 99mTc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma. Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis. To the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with 99mTc-sestaMIBI in case of hyperparathyroidism could be undertaken.Keywords
This publication has 38 references indexed in Scilit:
- Risk of Malignancy in Thyroid Incidentalomas Detected by18F-Fluorodeoxyglucose Positron Emission Tomography: A Systematic ReviewThyroid®, 2012
- Unusual F-18 Choline Uptake in Penile Metastasis From Prostate CancerClinical Nuclear Medicine, 2012
- Incidental Focal 18F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic CriteriaJournal of Nuclear Medicine, 2011
- Utility of 11C-Choline Imaging as a Supplement to F-18 FDG PET Imaging for Detection of Thyroid CarcinomaClinical Nuclear Medicine, 2011
- FDG-PET/CT and parathyroid carcinoma: Review of literature and illustrative case seriesWorld Journal of Clinical Oncology, 2011
- F-18 FDG-Avid Intrathyroidal Parathyroid Adenoma Mimicking Follicular NeoplasmClinical Nuclear Medicine, 2009
- C-11 Choline Versus F-18 Fluorodeoxyglucose for Imaging MeningiomasClinical Nuclear Medicine, 2009
- Silent Parathyroid Adenoma Mistakenly Interpreted on FDG-PET as Thyroid Cancer Metastasis in a Patient With Elevated Thyroglobulin and Negative I-131 Whole Body Scan and Removed by Radioguided Minimally Invasive SurgeryClinical Nuclear Medicine, 2008
- PET/CT of Skull Base Meningiomas Using 2-18F-Fluoro-L-Tyrosine: Initial ReportJournal of Nuclear Medicine, 2007
- Positron Emission Tomography in Acromegaly and Other Pituitary Adenoma PatientsNeuroendocrinology, 2006