Production of the gaseous signal molecule hydrogen sulfide in mouse tissues
Open Access
- 1 August 2008
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 106 (4), 1577-1585
- https://doi.org/10.1111/j.1471-4159.2008.05502.x
Abstract
The gaseous molecule hydrogen sulfide (H2S) has been proposed as an endogenous signal molecule and neuromodulator in mammals. Using a newly developed method, we report here for the first time the ability of intact and living brain and colonic tissue in the mouse to generate and release H2S. This production occurs through the activity of two enzymes, cystathionine‐γ‐lyase and cystathionine‐β‐synthase. The quantitative expression of messenger RNA and protein localization for both enzymes are described in the liver, brain, and colon. Expression levels of the enzymes vary between tissues and are differentially distributed. The observation that, tissues that respond to exogenously applied H2S can endogenously generate the gas, strongly supports its role as an endogenous signal molecule.Keywords
This publication has 33 references indexed in Scilit:
- Hydrogen sulfide mediates the vasoactivity of garlicProceedings of the National Academy of Sciences of the United States of America, 2007
- Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal DrugsGastroenterology, 2005
- Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating KATP ChannelsThe Journal of pharmacology and experimental therapeutics, 2005
- Cystathionine β‐synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNSThe FASEB Journal, 2005
- H 2 S Induces a Suspended Animation-Like State in MiceScience, 2005
- H2S generated by heart in rat and its effects on cardiac functionBiochemical and Biophysical Research Communications, 2004
- Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosaBiochemical Pharmacology, 2001
- Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous SystemPhysiological Reviews, 2001
- The possible role of hydrogen sulfide as an endogenous neuromodulatorJournal of Neuroscience, 1996
- Observations on the fate of cystathionine in rat brainLife Sciences, 1976