Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia
- 11 January 2007
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 136 (4), 673-676
- https://doi.org/10.1111/j.1365-2141.2006.06486.x
Abstract
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short‐ and long‐term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.Keywords
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