Motility and Chemotaxis in Campylobacter and Helicobacter
- 13 October 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 65 (1), 389-410
- https://doi.org/10.1146/annurev-micro-090110-102908
Abstract
Flagellar motility of Campylobacter jejuni and Helicobacter pylori influences host colonization by promoting migration through viscous milieus such as gastrointestinal mucus. This review explores mechanisms C. jejuni and H. pylori employ to control flagellar biosynthesis and chemotactic responses. These microbes tightly control the activities of σ54 and σ28 to mediate ordered flagellar gene expression. In addition to phase-variable and posttranslational mechanisms, flagellar biosynthesis is regulated spatially and numerically so that only a certain number of organelles are placed at polar sites. To mediate chemotaxis, C. jejuni and H. pylori combine basic chemotaxis signal transduction components with several accessory proteins. H. pylori is unusual in that it lacks a methylation-based adaptation system and produces multiple CheV coupling proteins. Chemoreceptors in these bacteria contain nonconserved ligand binding domains, with several chemoreceptors matched to environmental signals. Together, these mechanisms allow for swimming motility that is essential for colonization.Keywords
This publication has 119 references indexed in Scilit:
- CheV: CheW-like coupling proteins at the core of the chemotaxis signaling networkTrends in Microbiology, 2010
- Peptidoglycan Crosslinking Relaxation Promotes Helicobacter pylori's Helical Shape and Stomach ColonizationCell, 2010
- Chemotaxis signaling protein CheY binds to the rotor protein FliN to control the direction of flagellar rotation in Escherichia coliProceedings of the National Academy of Sciences of the United States of America, 2010
- Helicobacter pylori moves through mucus by reducing mucin viscoelasticityProceedings of the National Academy of Sciences of the United States of America, 2009
- Helicobacter pylori in Health and DiseaseGastroenterology, 2009
- A fixed-time diffusion analysis method determines that the three cheV genes of Helicobacter pylori differentially affect motilityMicrobiology, 2009
- Comparative Genomic and Protein Sequence Analyses of a Complex System Controlling Bacterial ChemotaxisMethods in Enzymology, 2007
- Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulenceMolecular Microbiology, 2006
- Evasion of Toll-like receptor 5 by flagellated bacteriaProceedings of the National Academy of Sciences of the United States of America, 2005
- Making sense of it all: bacterial chemotaxisNature Reviews Molecular Cell Biology, 2004