Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders
Open Access
- 18 June 2010
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 11 (6), 2566-2575
- https://doi.org/10.3390/ijms11062566
Abstract
Excess production of melanin or its abnormal distribution, or both, can cause irregular hyperpigmentation of the skin, leading to melasma and age spots. To date, various quasi-drugs that prevent or improve hyperpigmentary disorders have been developed and officially approved by the Ministry of Health, Labor and Welfare of Japan. Many of these inhibit the activity of tyrosinase, an enzyme required for melanin synthesis, for example, by competitive or non-competitive inhibition of its catalytic activity, by inhibiting its maturation, or by accelerating its degradation. In this review, we categorize the quasi-drugs developed in Japan to prevent or treat hyperpigmentary disorders, or both, and discuss perspectives for future development.This publication has 40 references indexed in Scilit:
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